Paramagnetic Cobalt(II) Complexes with Cyclam Derivatives: Toward 19F MRI Contrast Agents
نویسندگان
چکیده
منابع مشابه
Nickel(II) complexes of N–CH2CF3 cyclam derivatives as contrast agents for F magnetic resonance imaging
a Department of Inorganic Chemistry, Faculty of Science, Charles University (Univerzita Karlova), Hlavova 2030, 128 43 Prague 2, Czech Republic. Tel.: +420-22195-1261. Fax: +420-221951253. E-mail: [email protected]. b Department of Radiodiagnostic and Interventional Radiology, Magnetic Resonance Unit, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, Prague 4, 140 21 Czech R...
متن کاملResponsive paramagnetic chemical exchange saturation transfer MRI contrast agents
Molecular imaging research has shown great potential to assess the molecular compositions of tissues and provide critical information for clinical diagnoses [1]. These noninvasive assessments of molecular compositions may provide earlier diagnoses of pathologies, may predict therapeutic effects before the therapy is initiated and may provide earlier assessments of therapeutic effects soon after...
متن کاملNickel(II) complexes of N-CH2CF3 cyclam derivatives as contrast agents for (19)F magnetic resonance imaging.
Kinetically inert Ni(ii) complexes of N(1),N(8)-bis(2,2,2-trifluoroethyl)cyclams with hydrogen atoms or phosphonic acid groups in the N(4),N(11)-positions show significant (19)F NMR relaxation rate enhancement useful for 19-fluorine MRI imaging.
متن کاملGadolinium(III) 1,2-hydroxypyridonate-based complexes: toward MRI contrast agents of high relaxivity.
Prospective gadolinium(III) MRI contrast agent precursors [Gd-TREN-1,2-HOPO] (1) [TREN-1,2-HOPO = tris[(1-hydroxy-2-oxo-1,2-dihydropyridine-6-carboxamido)ethyl]amine] and [Gd-TREN-bis(Me-3,2-HOPO)-1,2-HOPO] (2) have been synthesized and characterized by relaxometric measurements. The water proton relaxivity values of 1 and 2 (20 MHz and 25 degrees C) are 9.5 and 9.3 mM(-)(1)s(-)(1), respectivel...
متن کاملEvaluation of Dendritic Gadolinium Complexes as MRI Contrast Agents
A series of dendritic gadolinium complexes based on dendrimers with 1,4,7,10-tetraazacyclododecane as the core were synthesized. Both diethylenetriaminepentaacetic acid and pyridoxamine were incorporated to the amine groups on the surface to give the dendritic ligands. These dendritic ligands were then reacted with gadolinium chloride to yield the corresponding dendritic gadolinium complexes. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Inorganic Chemistry
سال: 2020
ISSN: 0020-1669,1520-510X
DOI: 10.1021/acs.inorgchem.0c01216